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AZ-PFKFB3-67 quarterhydrate is potent and selective metabolic kinase PFKFB3 inhibitor, with IC50s of 11, 159 and 1130 nM for PFKFB3, PFKFB2 and PFKFB1 respectively.
| Molecular Weight | 460.01 |
| Formula | C26H25N5O3.1/4H2O |
| Form | Solid |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related PFKFB3 Products |
|---|
| PFK-015
PFK-015 is a potent and selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor. PFK-015 inhibits recombinant PFKFB3 with an IC50 value of 110 nM and inhibits PFKFB3 activity in cancer cells with an IC50 value of 20 nM. |
| 3PO
3PO is a novel small-molecule inhibitor of the PFKFB3 isozyme, attenuates the proliferation of several human malignant hematopoietic and adenocarcinoma cell lines with IC50 of 1.4-24 μM. |
| PFK-158
PFK-158, also known as ACT-PFK-158, is a potent and selective inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFK-2/FBPase) isoform 3 (PFKFB3) with potential antineoplastic activity. |
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