Free shipping on all orders over $ 500

Avacincaptad pegol

Cat. No. M45389

All AbMole products are for research use only, cannot be used for human consumption.

Avacincaptad pegol Structure

Price and Availability

For this product's availability, delivery time and price, please email inquiry@abmole.com directly or click the "Inquiry Now" button below.


Quality Control & Documentation
Biological Activity

Avacincaptad pegol is a nucleic acid aptamer and inhibitor of C5 complement that reduces inflammation-associated retinal pigment epithelial (RPE) damage.Avacincaptad pegol can be used to study stargardt macular dystrophy (STGD1) and geographic atrophy (GA).

Chemical Information
CAS Number 1613641-69-2
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Connie Kang. Drugs. Avacincaptad Pegol: First Approval

[2] Sunil S Patel, et al. Eye (Lond). Avacincaptad pegol for geographic atrophy secondary to age-related macular degeneration: 18-month findings from the GATHER1 trial

[3] Glenn J Jaffe, et al. Ophthalmology. C5 Inhibitor Avacincaptad Pegol for Geographic Atrophy Due to Age-Related Macular Degeneration: A Randomized Pivotal Phase 2/3 Trial

Related Complement System Products
Eculizumab

Eculizumab is a first-in-class recombinant humanized monoclonal antibody targeting complement protein C5. C5, which can only recognize humans, cannot bind to C5 of other species.

SB290157 trifluoroacetate salt

SB290157 is a selective antagonist of complement anaphylatoxin C3a receptor, a 74 amino acid proinflammatory peptide that is a potent chemotaxin for eosinophils, macrophages and mast cells.

JPE-1375

JPE-1375 is a complement C5a receptor 1 (C5aR1) antagonist. JPE-1375 effectively inhibits polymorphonuclear leukocyte mobilization (EC50=6.9 µM) and reduces TNF levels (EC50=4.5 µM) in mice.

Compstatin

Compstatinis is a 13-residue cyclic peptide, binds to complement component C3 and inhibits complement activation with IC50 of 12 μM. Compstatin exhibits exclusive specificity for primate C3s and does not bind either to C3s from lower mammalian species or to two structural homologs of C3, human C4 and C5.

Avacopan

Avacopan (CCX168) is a first-in-class, potent, selective and orally available complement 5a receptor (C5aR1 or CD88) antagonist with an IC50 of 0.1 nM.

  Catalog
Abmole Inhibitor Catalog




Keywords: Avacincaptad pegol supplier, Complement System, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.