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Auranofin is an inhibitor of thioredoxin reductase (TrxR) (IC50 = 20 nM; Ki = 4 nM for the NADPH-reduced form of human cytosolic TrxR). Auranofin induced the mitochondrial permeability transition via inhibition of mitochondrial TrxR. Auranofin also exhibits anti-inflammatory and immunosuppressive activities. Auranofin inhibits 5-lipoxygenase at high concentrations and stimulates LTA hydrolase at low concentrations.
| Molecular Weight | 678.48 |
| Formula | C20H34AuO9PS |
| CAS Number | 34031-32-8 |
| Solubility (25°C) | DMSO 40 mg/mL (Need ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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