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Atropine sulfate is a competitive muscarinic acetylcholine receptor antagonist. Atropine is a naturally occurring tropane alkaloid extracted from deadly nightshade (Atropa belladonna), Jimson weed (Datura stramonium), mandrake (Mandragora officinarum) and other plants of the family Solanaceae. Atropine is a competitive antagonist of the muscarinic acetylcholine receptors (acetylcholine being the main neurotransmitter used by the parasympathetic nervous system). Atropine dilates the pupils, increases heart rate, and reduces salivation and other secretions
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| Cell lines | |
| Preparation method | |
| Concentrations | |
| Incubation time | |
| Animal Experiment | |
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| Animal models | Male Sprague-Dawley rats |
| Formulation | purified water |
| Dosages | 1mg/5ml/kg |
| Administration | administrated orally |
| Molecular Weight | 338.41 |
| Formula | C17H23NO3 . 1/2 H2SO4 |
| CAS Number | 55-48-1 |
| Solubility (25°C) | Water 90 mg/mL DMSO 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related AChR/AChE Products |
|---|
| VU 0255035
VU 0255035 is a highly selective M1 muscarinic acetylcholine receptor (mAChR) antagonist (Ki = 14.87 nM). |
| Fesoterodine fumarate
Fesoterodine fumarate (Toviaz) is a novel muscarinic receptor antagonist. |
| SVT-40776
SVT-40776 is a novel M3 muscarinic receptor antagonist. |
| Aniracetam
Aniracetam is a compound that promotes intellectual development and neuroprotection. |
| Biperiden hydrochloride
Biperiden (KL 373) hydrochloride is a non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors, thereby inhibiting acetylcholine and enhancing dopamine signaling in the central nervous system. |
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