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Atosiban (RW22164; RWJ22164) is a nonapeptide competitive vasopressin/oxytocin receptor antagonist, and is a desamino-oxytocin analogue. Atosiban is the main tocolytic agent and has the potential for spontaneous preterm labor research.
| Molecular Weight | 994.19 |
| Formula | C43H67N11O12S2 |
| CAS Number | 90779-69-4 |
| Form | Solid |
| Solubility (25°C) | Water 16.67 mg/mL (ultrasonic) DMSO ≥ 16.67 mg/mL |
| Storage | Store at ≤ -20°C, dry, sealed |
[3] Vassilis Tsatsaris, et al. Drugs. Atosiban for preterm labour
| Related Oxytocin Receptor Products |
|---|
| Cligosiban
Cligosiban (PF-3274167) is a high-affinity, high oral bioavailability and good brain-penetrant nonpeptide oxytocin receptor (OTR) antagonist, with Ki of 9.5 nM. |
| Oxytocin acetate
Oxytocin acetate, a mammalian neurohypophysial hormone, is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin acetate can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma. |
| Carbetocin
Carbetocin is an oxytocin receptor agonist with a Ki of 7.1 nM. Carbetocin can crosse the blood-brain barrier and produces antidepressant-like activity via activation of oxytocin receptors in the CNS. |
| L-368,899 hydrochloride
L-368,899 hydrochloride is a potent, selective, orally bioavailable, non-peptide oxytocin receptor antagonist, with IC50s of 8.9 nM and 26 nM for rat uterus and human uterus oxytocin receptor, respectively. |
| Carbetocin acetate
Carbetocin acetate is an oxytocin (OT) analog and oxytocin receptor agonist that crosses the blood-brain barrier with a Ki of 7.1 nM. In addition, Carbetocin acetate has a high affinity for the chimeric N-terminal (E1) end of the oxytocin receptor, with a Ki = 1.17 μM. Carbetocin acetate can be used in studies related to postpartum hemorrhage. |
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