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Atopaxar (E5555) is a potent, orally active, selective and reversible thrombin receptor protease-activated receptor-1 (PAR-1) antagonist. Atopaxar, an antiplatelet agent, interferes with platelet signaling. Atopaxar can be used for the research of atherothrombotic disease.
| Molecular Weight | 527.63 |
| Formula | C29H38FN3O5 |
| CAS Number | 751475-53-3 |
| Form | Solid |
| Solubility (25°C) | DMSO 50 mg/mL (ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] T Wurster, et al. Hamostaseologie. Atopaxar
[2] T Wurster, et al. Hamostaseologie. Atopaxar. A novel player in antiplatelet therapy?
| Related PAR Products |
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| ML161
Parmodulin 2 (ML161) is an allosteric inhibitor of PAR1 with IC50 of 0.26 μM. |
| Vorapaxar
Vorapaxar (SCH 530348) is a potent and orally active thrombin receptor (PAR-1) antagonist with Ki of 8.1 nM. |
| Vorapaxar Sulfate
Vorapaxar is a first-in-class, potent and orally-active protease-activated receptor 1 (PAR-1) antagonist that blocks thrombin-mediated platelet activation without interfering with thrombin-mediated fibrin deposition. |
| ML354
ML354 is a potent and selective PAR4 (protease activated receptor-4) antagonist. |
| PAR-4 (1-6) (human)
PAR-4 (1-6) (human) is an N-terminal fragment of protease-activated receptor 4 (PAR4) that acts as a PAR4 agonist. |
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