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Atiprimod dihydrochloride is a jAK2 inhibitor (IC50 = 397 nM). Also inhibits STAT3 and STAT5 phosphorylation. Inhibits cell growth and induces apoptosis in cells expressing the JAK2V617F mutation.
| Molecular Weight | 409.52 |
| Formula | C22H44N2.2HCl |
| CAS Number | 130065-61-1 |
| Solubility (25°C) | DMSO 4.1 mg/mL (with gentle warming) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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