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ASR-490 reduces the viability of HCT116 and SW620 cells by downregulating Notch1 signaling. ASR-490 overcomes Notch1 overexpression and inhibits the growth of HCT/Notch1 transfectants. ASR-490 inhibits the tumor growth in control (pCMV/HCT116) and Notch1/HCT116 in xenotransplanted mice.
| Molecular Weight | 575.69 |
| Formula | C34H41NO7 |
| CAS Number | 2690312-67-3 |
| Form | Solid |
| Solubility (25°C) | DMSO 20 mg/mL |
| Storage | Powder -20°C |
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FLI-06 is a novel inhibitor of Notch signaling with EC50 of 2.3 μM. |
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LY900009 is a potent, first-in-class Notch inhibitor with IC50 of 0.27 nM. |
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Tangeretin is a flavonoid from citrus fruit peels, and is also selected as a Notch-1 inhibitor, which plays an important role in anti-inflammatory responses and neuroprotective effects in several disease models. |
| IMR-1
IMR-1 is a first-in-class, cell-permeable inhibitor of the Notch transcription activation complex, with an IC50 of 26 μM. IMR-1 prevents Maml1 from recruiting to the Notch ternary complex (NTC) in chromatin, inhibits transcription of Notch target genes, and has antitumor activity. |
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NVS-ZP7-4 is a potent ZIP7 Inhibitor, which inhibits Notch signaling with IC50 of 0.13 uM in HES-Luc reporter gene assays, selectively induces apoptosis and ER stress. |
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Products are for research use only. Not for human use. We do not sell to patients.
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