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ASP2535 

Cat. No. M30010

All AbMole products are for research use only, cannot be used for human consumption.

ASP2535  Structure

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Quality Control & Documentation
Biological Activity

ASP2535 is a potent, orally bioavailable, selective, brain permeable and centrally-active glycine transporter-1 (GlyT1) inhibitor. ASP2535 can improve cognitive impairment in animal models of schizophrenia and Alzheimer's disease.

Chemical Information
Molecular Weight 382.42
Formula C22H18N6O
CAS Number 374886-51-8
Form Solid
Storage Powder -20°C
References

[1] Katsuya Harada, et al. Eur J Pharmacol. A novel glycine transporter-1 (GlyT1) inhibitor, ASP2535 (4-[3-isopropyl-5-(6-phenyl-3-pyridyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole), improves cognition in animal models of cognitive impairment in schizophrenia and Alzheimer's disease

Related GlyT Products
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Bitopertin (RG1678,RO-4917838) is a potent inhibitor of glycine transporter 1 (GlyT1), with Ki of 8.1 nM for human hGlyT1b and IC50 of 22-25 nM in Chinese hamster ovary cells.

LY 2365109 hydrochloride

LY 2365109 hydrochloride is a potent and selective GlyT1 inhibitor.

  Catalog
Abmole Inhibitor Catalog




Keywords: ASP2535  supplier, GlyT, inhibitors, activators

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