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ASP7663 is a selective TRPA1 activator (EC50 values are ~0.5 μM in human, mouse and rat). ASP7663 stimulates 5-HT release from QGP-1 cells.
ASP7663 exhibits an abdominal analgesic effect in vivo. ASP7663 significantly improves the loperamide-induced delay in colonic transit in mice. ASP7663 (orally, 0.3 and 1 mg/kg) significantly shortens the prolonged bead expulsion time caused by loperamide. ASP7663 (orally, 1 and 3 mg/kg) exhibits inhibitory effects on colorectal distension in rat.
| Molecular Weight | 263.26 |
| Formula | C14H14FNO3 |
| CAS Number | 1190217-35-6 |
| Solubility (25°C) | DMSO 45 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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Products are for research use only. Not for human use. We do not sell to patients.
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