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Asciminib (ABL001) hydrochloride is a potent and selective allosteric BCR-ABL1 inhibitor, which inhibits Ba/F3 cells grown with an IC50 of 0.25 nM. Asciminib (ABL001) hydrochloride binds to the myristoyl pocket of ABL1 and induces the formation of an inactive kinase conformation.
| Molecular Weight | 486.30 |
| Formula | C20H19Cl2F2N5O3 |
| CAS Number | 2119669-71-3 |
| Solubility (25°C) | DMSO 95 mg/mL |
| Storage | 4°C, dry, sealed |
| Related Src-bcr-Abl Products |
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| Bosutinib
Bosutinib (SKI-606) is a novel Bcr-Abl inhibitor with IC50 values of 0.1 to 0.3 umol/L. |
| Dasatinib
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| DCC-2036
DCC-2036 is an ABL inhibitor with IC50 of 0.8 and 2 nM for u-ABL1native and p-ABL1native, respectively. |
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