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Arylquin 1

Cat. No. M8487

All AbMole products are for research use only, cannot be used for human consumption.

Arylquin 1 Structure

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Biological Activity

Arylquin 1 is a potent secretagogue of the tumor suppressor protein prostate apoptosis response-4 (Par-4), selectively inducing apoptosis in a variety of cancer cells. Arylquin 1 acts by binding to vimentin, displacing Par-4 from vimentin for secretion. Arylquin 1 produced a dose-dependent secretion of Par-4 at nanomolar concentrations.

Chemical Information
Molecular Weight 281.33
Formula C17H16FN3
CAS Number 1630743-73-5
Solubility (25°C) DMSO: 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Kyoung-Jin Min, et al. Arylquin 1, a potent Par-4 secretagogue, induces lysosomal membrane permeabilization-mediated non-apoptotic cell death in cancer cells

[2] Ravshan Burikhanov, et al. Arylquins target vimentin to trigger Par-4 secretion for tumor cell apoptosis

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