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Arn-3236 is a selective inhibitor of salt-induced kinase 2 (SIK2) with an IC50 value of <1 nM, 21.63 nM and 6.63 nM against SIK2, SIK1 and SIK3, respectively. It has antitumor activity.
| Molecular Weight | 336.41 |
| Formula | C19H16N2O2S |
| CAS Number | 1613710-01-2 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Salt-inducible Kinase Products |
|---|
| HG-9-91-01
HG-9-91-01 is a potent and highly selective salt-inducible kinase (SIK) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3 respectively. |
| YKL-05-099
YKL-05-099 is a salt-inducible kinase (SIK) inhibitor. YKL-05-099 binds to SIK1 and SIK3 with IC50s of ~10 and ~30 nM, respectively. YKL-05-099 has slightly less potent SIK2-inhibitory (IC50=40 nM). |
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