All AbMole products are for research use only, cannot be used for human consumption.
Aristolactam I is an AQP1 inhibitor and Aristolochic acid I metabolite. Aristolactam I downregulates Twist1 expression, increases E-cadherin expression, and activates the TGF-β/Smad signaling pathway. Aristolactam I is mainly used in the study of breast cancer and kidney diseases such as renal interstitial fibrosis.
| Molecular Weight | 293.27 |
| Formula | C17H11NO4 |
| CAS Number | 13395-02-3 |
| Solubility (25°C) | DMSO 10 mg/mL |
| Storage | 4°C, protect from light |
| Related AQP Products |
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| TGN 020
TGN 020 is a aquaporin 4 (AQP4) channel blocker. |
| Bacopaside II
Bacopaside II, an extract from the medicinal herb Bacopa monnieri, blocks the Aquaporin-1 (AQP1) water channel and impairs migration of cells that express AQP1. Bacopaside II induces cell cycle arrest and apoptosis. |
| TC AQP1 1
TC AQP1 1 (m-Phenylenediacrylic acid) is a potent AQP1 inhibitor. TC AQP1 1 inhibits AQP1-mediated water flux in oocytes, with an IC50 of 8 μM. |
| AqF026
AqF026 is an agonist of the water channel aquaporin-1. AqF026 potentiated the channel activity of human AQP1 by >20% but had no effect on channel activity of AQP4. AqF026 enhanced the osmotic transport of water across the peritoneal membrane but did not affect the osmotic gradient, the transport of small solutes, or the localization and expression of AQP1 on the plasma membrane in a mouse model of peritoneal dialysis. |
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Products are for research use only. Not for human use. We do not sell to patients.
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