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Arglabin ((+)-Arglabin, a natural product isolated from Artemisia annua, is an inhibitor of the NLRP3 inflammasome. Arglabin has anti-inflammatory and anti-tumor activity. Arglabin's antitumor activity is achieved by inhibiting farnesyl metastase and activating the RAS proto-oncogene.
| Molecular Weight | 246.30 |
| Formula | C15H18O3 |
| CAS Number | 84692-91-1 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 100 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Tracey L Freeman, et al. Front Immunol. Targeting the NLRP3 Inflammasome in Severe COVID-19
[5] Shabir H Lone, et al. Chem Biol Interact. Arglabin: From isolation to antitumor evaluation
| Related NLR Products |
|---|
| Nodinitib-1
Nodinitib-1 (ML130) is a potent and selective inhibitor of NOD1 with IC50 of 0.56 μM, inhibits NF-κB activation, exhibits 36-fold selectivity over NOD2. |
| Ruscogenin
Ruscogenin is an important steroid saponin extracted from Ophiopogon japonicum. It alleviates blood-brain barrier dysfunction induced by cerebral ischemia by inhibiting TXNIP/NLRP3 inflammatory body activation and MAPK pathway, and has significant anti-inflammatory and antithrombotic activities. |
| Procyanidin-B2
Procyanidin B2 is a natural flavonoid with anti-tumor and anti-oxidation effects. Procyanidin B2 inhibited NLRP3 inflammasome activation via suppression of AP-1 pathway. |
| Oridonin
Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity. Oridonin (NSC-250682) also acts as an inhibitor of AKT, with IC50 values of 8.4 and 8.9 μM for AKT1 and AKT2, respectively. |
| Shionone
Shionone, isolated from Aster Tataricus, is a triterpenoid compound with antitussive and anti-inflammatory activities. Shionone has a unique six-membered four-ring framework and a 3-oxygen-4-monomethyl structure. |
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