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Arctiin

Cat. No. M3925

All AbMole products are for research use only, cannot be used for human consumption.

Arctiin Structure
Synonym:

Arctii; NSC 315527; Arctigenin-4-glucoside

Size Price Availability Quantity
20mg USD 40 In stock
50mg USD 50 In stock
100mg USD 65 In stock
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Biological Activity

Arctiin has shown to be a suppressor of cyclin D1 protein expression in multiple types of human tumor cells, such as osteosarcoma, lung, colorectal, cervical, breast, melanoma, and prostate cancer. Arctiin has shown antiviral activity against influenza A when used along or in combination with oseltamivir. It was recently reported that arctiin induces growth inhibition in human prostate cancer PC-3 cells. Arctiin induces growth inhibition and dephosphorylates the tumor-suppressor retinoblastoma protein in human immortalized keratinocyte HaCaT cells. The growth inhibition caused by arctiin is associated with the down-regulation of cyclin D1 protein expression. Arctiin has a protective effect on ROS-induced cell dysfunction in HHDPCs and may therefore be useful for alopecia prevention and treatment strategies.

Chemical Information
Molecular Weight 534.55
Formula C27H34O11
CAS Number 20362-31-6
Form Solid
Solubility (25°C) DMSO 5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Bae S, et al. Biol Res. Arctiin blocks hydrogen peroxide-induced senescence and cell death though microRNA expression changes in human dermal papilla cells.

[2] Matsuzaki Y, et al. Oncol Rep. Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression.

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Keywords: Arctiin, Arctii; NSC 315527; Arctigenin-4-glucoside supplier, inhibitors, activators

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