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AR antagonist 3 

Cat. No. M29958

All AbMole products are for research use only, cannot be used for human consumption.

AR antagonist 3  Structure

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Quality Control & Documentation
Biological Activity

AR antagonist 3 is a potent and selective androgen receptor (AR) antagonist with an IC50 of 0.47 µM. AR antagonist 3 exhibits a dose-dependent decrease of the FRET signal (IC50= 18.05 μM). AR antagonist 3 shows effective inhibition on tumor growth when administered intratumorally.

Chemical Information
Molecular Weight 306.38
Formula C15H18N2O3S
CAS Number 349573-58-6
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Thanakorn Pungsrinont, et al. Int J Mol Sci. Role of PI3K-AKT-mTOR Pathway as a Pro-Survival Signaling and Resistance-Mediating Mechanism to Therapy of Prostate Cancer

[2] Jinjing Wu, et al. Drug Des Devel Ther. Melatonin Attenuates Anoxia/Reoxygenation Injury by Inhibiting Excessive Mitophagy Through the MT2/SIRT3/FoxO3a Signaling Pathway in H9c2 Cells

[3] Satoshi Kawaguchi, et al. Am J Physiol Heart Circ Physiol. β3-Adrenergic receptor blockade reduces mortality in endotoxin-induced heart failure by suppressing induced nitric oxide synthase and saving cardiac metabolism

[4] Phumvadee Wangtrakuldee, et al. J Steroid Biochem Mol Biol. A 3-(4-nitronaphthen-1-yl) amino-benzoate analog as a bifunctional AKR1C3 inhibitor and AR antagonist: Head to head comparison with other advanced AKR1C3 targeted therapeutics

[5] Alessia Scatena, et al. ACS Chem Neurosci. 3-(Fur-2-yl)-10-(2-phenylethyl)-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one, a novel adenosine receptor antagonist with A(2A)-mediated neuroprotective effects

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Keywords: AR antagonist 3  supplier, Androgen Receptor, inhibitors, activators

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