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AQ4

Cat. No. M7616

All AbMole products are for research use only, cannot be used for human consumption.

AQ4 Structure

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Biological Activity

AQ4 is a chemically stable cytotoxic agent used as a topoisomerase II inhibitor and DNA intercalator. The compound is a potent cytotoxic agent in many human tumor lines, including those derived from human pancreatic adenocarcinoma. Compound N - oxide is a hypoxic-activated topoisomerase targeting precursor compound.

Chemical Information
Molecular Weight 412.48
Formula C22H28N4O4
CAS Number 70476-63-0
Solubility (25°C) DMSO: ≥10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Maarten J Titulaer, et al. Overlapping demyelinating syndromes and anti–N-methyl-D-aspartate receptor encephalitis

[2] Edjah K Nduom, et al. Characterization of the blood-brain barrier of metastatic and primary malignant neoplasms

[3] Kaye J Williams, et al. In vivo activation of the hypoxia-targeted cytotoxin AQ4N in human tumor xenografts

[4] Swita Raghava, et al. AQ4, an antitumor anthracenedione, inhibits endothelial cell proliferation and vascular endothelial growth factor secretion: implications for the therapy of ocular neovascular disorders

[5] Sally J Atkinson, et al. Examination of the distribution of the bioreductive drug AQ4N and its active metabolite AQ4 in solid tumours by imaging matrix-assisted laser desorption/ionisation mass spectrometry

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Abmole Inhibitor Catalog




Keywords: AQ4 supplier, inhibitors, activators

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