All AbMole products are for research use only, cannot be used for human consumption.
Aprotinin is a competitive serine protease inhibitor. Aprotinin reversibly binds to and blocks the enzymatic active site. Aprotinin inhibits a range of serine proteases including trypsin, chymotrypsin, kallikrein and plasmin.
Activity: 5868KIU/mg (4.51TIU/mg)
Cells. 2021 Feb 18;10(2):430.
Knockdown of AKT3 Activates HER2 and DDR Kinases in Bone-Seeking Breast Cancer Cells, Promotes Metastasis In Vivo and Attenuates the TGFβ/CTGF Axis
Aprotinin purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | mouse G8-1 and C2C12 skeletal muscle myoblasts |
| Preparation method | Olating mouse G8- 1 myoblasts DMEM + 20% FBS (maintenance medium), in which they remain undifferentiated. When cells reache approximately 40-50% confluence, adding different protease inhibitors to the culture media and incubating cells overnight. Then switching cells to differentiation-promoting media (DMEM + 10% horse serum ?protease inhibitor) and incubating for 7 days. |
| Concentrations | 2 TIU/ml |
| Incubation time | 12hrs |
| Animal Experiment | |
|---|---|
| Animal models | Male Wistar rats |
| Formulation | physiological saline |
| Dosages | 1.5 mg/kg and 3 mg/kg/h, 3 mg/kg and 6 mg/kg/h up to 5 mg/kg and 10 mg/kg/h ological saline |
| Administration | bolus injection followed by a maintenance infusion(i.p.) |
| Molecular Weight | 6511.48 |
| Formula | C284H432N84O79S7 |
| CAS Number | 9087-70-1 |
| Solubility (25°C) | Water ≥ 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Serine/Threonine Protease Products |
|---|
| PMSF
PMSF is an irreversible serine/cysteine protease inhibitor. PMSF is commonly used in the preparation of cell lysates. |
| AEBSF HCl
AEBSF HCl is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, plasmin, thrombin, and trypsin. |
| Nafamostat Mesylate
Nafamostat Mesylate is a synthetic serine protease inhibitor with concomitant anticoagulant activity. |
| UKI-1
UKI-1 is a novel synthetic inhibitor of the urokinase-type plasminogen activator, which inhibits the invasive capacity of carcinoma cells with a Ki of 0.41 μM. |
| Upamostat
Upamostat (WX-671, umorestat) is a Urokinase-type Plasminogen Activator (uPA) inhibitor. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
