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Aprindine hydrochloride is a class Ib antiarrhythmic and hERG channel blocker. Aprindine shows structure similarities to lidocaine and procainamide and is effective in treatment of patients with ventricular premature depolarizations, ventricular tachycardia, and supraventricular arrhythmias. Aprindine inhibits the activation of bovine brain cyclic 3′:5′-nucleotide phosphodiesterase (EC 3.1.4.17) by calmodulin and inhibits calmodulin-stimulated Ca-ATPase (ATP phosphohydrolase EC 3.6.1.3) activity.
| Molecular Weight | 358.95 |
| Formula | C22H30N2 · HCl |
| CAS Number | 33237-74-0 |
| Solubility (25°C) | Water: ≥10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Luisa Ibez, et al. Population-based drug-induced agranulocytosis
[2] C L Raehl, et al. Drug-induced torsade de pointes
[3] H Tanaka, et al. Electrophysiologic actions of aprindine in rabbit atrioventricular node
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