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Apratoxin S4

Cat. No. M28192

All AbMole products are for research use only, cannot be used for human consumption.

Apratoxin S4 Structure

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Quality Control & Documentation
Biological Activity

Apratoxin S4 (Apra S4) is a potent Sec61 inhibitor that prevents cotranslational translocation of secretory proteins into the endoplasmic reticulum (ER). Apratoxin S4 has antiviral effects against some flaviviruses with IC50 values ranging from 0.46 nM to 170 nM, and inhibits retinal vascular cell activation by suppressing multiple angiogenic pathways. Apratoxin S4 can be used for the research of viral infections, angiogenic diseases and cancers.

Chemical Information
Molecular Weight 828.11
Formula C44H69N5O8S
CAS Number 1334149-94-8
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Marie O Pohl, et al. ACS Infect Dis. Sec61 Inhibitor Apratoxin S4 Potently Inhibits SARS-CoV-2 and Exhibits Broad-Spectrum Antiviral Activity

[2] Weijing Cai, et al. Curr Res Pharmacol Drug Discov. Inhibition of cotranslational translocation by apratoxin S4: Effects on oncogenic receptor tyrosine kinases and the fate of transmembrane proteins produced in the cytoplasm

[3] Beiying Qiu, et al. Invest Ophthalmol Vis Sci. Apratoxin S4 Inspired by a Marine Natural Product, a New Treatment Option for Ocular Angiogenic Diseases

[4] Qi-Yin Chen, et al. J Med Chem. Improved total synthesis and biological evaluation of potent apratoxin S4 based anticancer agents with differential stability and further enhanced activity

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