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Apramycin is an aminoglycoside antibiotic, which binds to the deep groove of the RNA.Apramycin inhibits A. pleuropneumoniae FMV 87-682 with MIC50 of 8 mg/L. Apramycin (1/4 MIC) in the medium decreases the rate of growth of the bacterial strains tested and causes the PAE up to 5 hours. Apramycin significantly reduces the haemolytic activity of A. pleuropneumoniae. Apramycin induces translation errors, as assayed by incorporation of leucine, isoleucine and serine, although this effect occurs only to a limited extent, in cell-free systems from Escherichia coli programmed with poly(U). Apramycin inhibits the translocation step of protein synthesis both in vivo, in protoplasts of Bacillus megaterium, and in vitro, in cell-free systems from E. coli.
| Molecular Weight | 637.66 |
| Formula | C21H41N5O11.xH2O4S |
| CAS Number | 65710-07-8 |
| Solubility (25°C) | Water ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Yuqi Yang, et al. Wild-type cutoff for Apramycin against Escherichia coli
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