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MDK83190 is a potent apoptosis activator, induces Apaf-1 oligomerization, increases procaspase-9 processing and subsequent caspase-3 activation in a cyto c-dependent manner. MDK83190 (Apoptosis Activator 2) strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells. MDK83190 promotes apoptosome formation and activates caspase-9/caspase-3 pathway. MDK83190 selectively induces tumor cell apoptosis.
Cell Death Dis. 2024 Feb;15(2):129.
Deubiquitinase Mysm1 regulates neural stem cell proliferation and differentiation by controlling Id4 expression
MDK83190 purchased from AbMole
| Molecular Weight | 306.14 |
| Formula | C15H9Cl2NO2 |
| CAS Number | 79183-19-0 |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Su-Been Lee, et al. Induction of p53-Dependent Apoptosis by Prostaglandin A 2
[4] Vitaliy O Kaminskyy, et al. Free radicals in cross talk between autophagy and apoptosis
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