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Apilimod mesylate is a potent IL-12/IL-23 inhibitor, which inhibits the IL-12 production in cultures of IFN-γ/LPS–stimulated human PBMCs with an IC50 of 10 nM. Apilimod mesylate inhibited IFN-γ production induced by either IFN-γ/SAC or SAC in human PBMCs, with an IC50 of approximately 20 nM.
In vivo, oral administration of either 5 mg/kg or 20 mg/kg Apilimod mesylate (STA-5326) reduced the severity of EAU on day 14 and 18. In addition, mice treated with 20 mg/kg STA-5326 showed significantly decreased severity of EAU by histopathological analysis.
| Molecular Weight | 610.7 |
| Formula | C25H34N6O8S2 |
| CAS Number | 870087-36-8 |
| Solubility (25°C) | Water 60 mg/mL DMSO 8 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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