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AP-18 is a selective TRPA1 channel blocker. AP-18 blocks activation of TRPA1 by 50 μM Cinnamaldehyde with an IC50 of 3.1 μM and 4.5 μM for human and mouse TRPA1, respectively. AP-18 attenuated 30 μM AITC-induced Yo-Pro uptake in a concentration-dependent manner, with an IC50 of 10.3 μM. Transient receptor potential A1 (TRPA1) plays a central role for chemical sensing in the pain pathway. AP-18 is a novel TRPA1 channel blocker. It reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation. AP-18 reverses CFA-induced mechanical hyperalgesia in mice.
| Molecular Weight | 209.67 |
| Formula | C11H12ClNO |
| CAS Number | 55224-94-7 |
| Solubility (25°C) | DMSO ≥ 90 mg/mL |
| Storage | 4°C, protect from light, dry, sealed |
[1] Adam Honeybrook, et al. A Novel Laryngoscope With an Adjustable Distal Tip
[5] A N Glazer, et al. The structure of a "simple" phycobilisome
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