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Antimalarial agent 12

Cat. No. M38782

All AbMole products are for research use only, cannot be used for human consumption.

Antimalarial agent 12 Structure

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Quality Control & Documentation
Biological Activity

Antimalarial agent 12 is a potent antimalarial agent. Antimalarial agent 12 shows growth inhibition on P. falciparum Dd2 Strain (EC50=155 nM), 3D7 strain (EC50=136 nM). Antimalarial agent 12 has CC50 values of 10,000 to 50,000 nM for HEK-293 and hPHep cell lines.

Chemical Information
Molecular Weight 505.79
Formula C26H18BrClN2O2
CAS Number 2715225-58-2
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Bishnu Prasad Raiguru et al. Bioorg Chem. Recent developments in the synthesis of hybrid antimalarial drug discovery

[2] Anwei Hou et al. Chembiochem. Cladosporin, A Highly Potent Antimalaria Drug?

[3] Jorddy N Cruz et al. Comb Chem High Throughput Screen. Antimalarial Hemozoin Inhibitors (β-Hematin Formation Inhibition): Latest Updates

[4] Livia Neves Borgheti-Cardoso et al. Future Med Chem. Turning Plasmodium survival strategies against itself

[5] Duong Nhu et al. Bioorg Med Chem Lett. Antimalarial 3-arylamino-6-benzylamino-1,2,4,5-tetrazines

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