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Anti-inflammatory agent 49 is a potent inhibitor of Drp1-Fis1 interaction and can reduce FIS1-mediated mitochondrial dysfunction. Anti-inflammatory agent 49 inhibits GTPase with IC50 of 270 nM in vitro.
Anti-inflammatory agent 49 can be used in the study of diseases caused by mitochondrial dysfunction. Anti-inflammatory agent 49 (10 mg/kg; i.p.; scored every 8 h for 72 h) improved mouse survival at all LPS doses tested at the different LPS doses (10 to 16.6 mg/kg).
| Molecular Weight | 466.52 |
| Formula | C21H22N8O3S |
| CAS Number | 851471-44-8 |
| Solubility (25°C) | DMSO 80 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Dynamin Products |
|---|
| Dynasore
Dynasore is a cell-permeable, reversible non-competitive dynamin inhibitor of GTPase activity of dynamin 1/2, with IC50 of 15 μM. |
| Mdivi-1
Mdivi-1 is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) with IC50 of 1-10 μM. |
| Hydroxy-Dynasore
Hydroxy-Dynasore is a cell permeable and potent dynamin inhibitor that prevents uptake of recombinant botulinum neurotoxin a heavy chain binding domain (BoNT/A-Hc). |
| TAT-P110
TAT-P110, a peptide inhibitor of Drp1-Fis1 interaction, reduces pathology in numerous models of neurodegeneration, ischemia, and sepsis without blocking the physiological functions of Drp1. |
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Products are for research use only. Not for human use. We do not sell to patients.
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