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CD137 (also known as 4-1BB) is an inducible cell surface receptor, a member of the tumornecrosis factor receptor (TNFR) superfamily. It is encoded by tumor necrosis factor receptor superfamily member 9 (TNFRSF9) gene. It is widely expressed on the surface of activated T cells, NK cells and other human immune cells. Its ligand is CD137L, also a member of TNFSF, and is an inducible costimulatory receptor expressed on activated CD4+ and CD8+ T cells, NKT, NK cells, DC, macrophages, eosinophils, neutrophils, and mast cells, especially on CD8+ T cells. CD137/CD137L modulates T cell-mediated immune responses by transmitting activation, proliferation, or apoptosis signals between immune cells. Activated signal transduction of CD137 stimulates NK and T cell proliferation and produces antitumor activity, as well as long-lasting memory responses. Activated 4-1BB mab was used to activate 4-1BB, which recruited TNFR-related factors TRAF1 and TRAF2 to form heterotrimers. Signal transduction was enhanced through C-Jun N-terminal kinase (JNK) pathway and extracellular signal-regulated kinase (ERK) pathway. The main transcription factor NF-κB regulates the 4-1BB signal, stimulates T cells and antigen presenting cells to proliferate and secrete cytokines, and improves the level of anti-tumor immune response.
Expression host: HEK-293 cells
Purity: > 95%
Endotoxin: < 0.1EU/μg
| Form | Liquid |
| Storage | Stored at 2~8°C, stable for one year after receipt. After divided, stored at -20°C for 6 months and at -80°C for 12 months. |
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