All AbMole products are for research use only, cannot be used for human consumption.
Angiotensin II human (Angiotensin II) acetate is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human acetate plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human acetate stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human acetate induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human acetate also induces apoptosis. Angiotensin II human acetate induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway.
| Molecular Weight | 1106.23 |
| CAS Number | 68521-88-0 |
| Solubility (25°C) | Water 25 mg/mL |
| Storage | -20°C, dry, sealed |
[3] Tao Yang, et al. Gut dysbiosis is linked to hypertension
[4] William G McMaster, et al. Inflammation, immunity, and hypertensive end-organ damage
| Related Angiotensin Receptor Products |
|---|
| Azilsartan medoxomil
Azilsartan Medoxomil is an effective angiotensin II Type 1 (AT1) receptor antagonist that inhibits RAAS more than 10,000 times more selectively than AT2, and is used to study hypertension. |
| Azilsartan
Azilsartan (TAK-536) is an angiotensin II type 1 (AT1) receptor antagonist with IC50 of 2.6 nM. Azilsartan induces ROS formation and apoptosis in HepG2 cells. Azilsartan shows neuroprotective and anticancer activity. |
| PD 123319 ditrifluoroacetate
PD 123319 ditrifluoroacetate is a potent, selective, non-peptide angiotensin AT2 receptor antagonist. |
| Losartan potassium
Losartan potassium is a selective non-peptide angiotensin AT1 receptor antagonist. |
| Eprosartan Mesylate
Eprosartan is a nonpeptide angiotensin II receptor antagonist, [3H]-eprosartan binds to the AT1 receptor with KD of 0.83 nM in rat vascular smooth muscle cells. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
