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Anecortave acetate is a potent ocular vascular inhibitor that inhibits angiogenic factor-induced neointima formation and also increases fibrinogen activator inhibitor 1 (PAI-1) mRNA expression.Anecortave acetate can be used in studies related to ocular neovascularization diseases.
| Molecular Weight | 386.48 |
| Formula | C23H30O5 |
| CAS Number | 7753-60-8 |
| Form | Solid |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Abbot F Clark. Surv Ophthalmol. Preclinical efficacy of anecortave acetate
[3] Jim Heaton, et al. Surv Ophthalmol. Preclinical safety of anecortave acetate
[4] Sophie J Bakri, et al. Expert Opin Investig Drugs. Anecortave acetate
| Related PAI-1 Products |
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| PAI-039
PAI-039 is an inhibitor of plasminogen activator inhibitor-1 (PAI-1). |
| Loureirin B
Loureirin B is a flavonoid isolated from The blood tree of Pterygophyllum SPP. It is an inhibitor of PAI-1 with IC50 value of 26.10 μM. Loureirin B can inhibit the phosphorylation of KATP, ERK and JNK at the same time, showing an anti-diabetes effect. |
| TM5275 sodium salt
TM5275 sodium is an orally available, potent and selective plasminogen activator inhibitor (PAI-1) with an IC50 of 6.95 μM that delivers antithrombotic benefits devoid of bleeding effect in nonhuman primates. |
| TM5441
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| Toddalolactone
Toddalolactone, a main component of Toddalia asiatica, inhibits the activity of recombinant human plasminogen activator inhibitor-1 (PAI-1), with an IC50 value of 37.31 μM. |
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