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Amylin amide, human is a 37-amino acid polypeptide, it is a pancreatic hormone cosecreted with insulin that exerts unique roles in metabolism and glucose homeostasis. Amylin amide, human inhibits glucagon secretion, delays gastric emptying, and acts as a satiety agent.
| Cell Experiment | |
|---|---|
| Cell lines | MCF-7 cells |
| Preparation method | MCF-7 cells endogenously express human amylin receptor CTR1 and CTR2. Stimulation of the receptor with Amylin, amide, human results in the production of cAMP. Amylin, amide, human (0.001 nM-1000 μM) results in an EC50 of 35.2±7.5 nM. |
| Concentrations | 0.001 nM-1000 μM |
| Incubation time | |
| Animal Experiment | |
|---|---|
| Animal models | Swiss male mice (8 weeks old) |
| Formulation | |
| Dosages | 400 μg peptide /kg body weight |
| Administration | Subcutaneous route; 24 hours |
| Molecular Weight | 3903.28 |
| Formula | C165H261N51O55S2 |
| CAS Number | 122384-88-7 |
| Solubility (25°C) | Soluble in water |
| Storage | -20°C, dry, sealed |
[1] Thayna Sisnande, et al. PLoS One. Monoconjugation of Human Amylin with Methylpolyethyleneglycol
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