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Ampreloxetine (TD-9855) hydrochloride is an orally active and CNS-penetrant inhibitor of Norepinephrine transporter (NET) and Serotonin 5-HT uptake transporter (SERT). Ampreloxetine hydrochloride binds norepinephrine transporters (NET) and serotonin transporters (SERT) with EC50 values of 11.7 ng/mL and 50.8 ng/mL, respectively, in plasma.
| Molecular Weight | 357.8 |
| Formula | C18H19ClF3NO |
| CAS Number | 1227056-87-2 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Serotonin Transporter Products |
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| Adoxosidic acid
Adoxosidic acid is a SERT enhancer which can be extracted from N. jatamansi. |
| Amitriptyline
Amitriptyline (MK-230, N-750, Ro41575) is an inhibitor of the serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki values of 3.45 nM and 13.3 nM, respectively, and also inhibits the histamine receptor H1, the histamine receptor H4, 5-HT2, and the Sigma 1 receptor with Ki values of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. It can also inhibit histamine receptor H1, histamine receptor H4, 5-HT2 and Sigma 1 receptor with Ki values of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively, and can be used in studies of depression and neuropathic pain. |
| Centanafadine hydrochloride
Centanafadine hydrochloride is a potential first-in-class norepinephrine (NE), dopamine (DA), and 5-hydroxytryptamine (5-HT) reuptake inhibitor (NDSRI) with IC50 values of 6 nM, 38 nM, and 83 nM, respectively. It can be used in studies related to attention-deficit/hyperactivity disorder (ADHD). |
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