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Amivantamab

Cat. No. M24975

All AbMole products are for research use only, cannot be used for human consumption.

Amivantamab Structure
Synonym:

JNJ-61186372

Size Price Availability Quantity
100ug USD 170 In stock
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Quality Control & Documentation
Biological Activity

Amivantamab (JNJ-61186372) is a human EGFR-MET bispecific antibody with immune anticancer activity. Amivantamab inhibits ligand binding, promotes endocytosis and degradation of receptor-antibody complexes, and induces Fc-dependent cytokinesis in macrophages and antibody-dependent cytotoxicity in natural killer cells.

Chemical Information
CAS Number 2171511-58-1
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Byoung Chul Cho, et al. Future Oncol. MARIPOSA: phase 3 study of first-line amivantamab + lazertinib versus osimertinib in EGFR-mutant non-small-cell lung cancer

[2] Keunchil Park, et al. J Clin Oncol. Amivantamab in EGFR Exon 20 Insertion-Mutated Non-Small-Cell Lung Cancer Progressing on Platinum Chemotherapy: Initial Results From the CHRYSALIS Phase I Study

[3] Yahiya Y Syed. Drugs. Amivantamab: First Approval

[4] No authors listed. Amivantamab

[5] Joost Neijssen, et al. J Biol Chem. Discovery of amivantamab (JNJ-61186372), a bispecific antibody targeting EGFR and MET

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Keywords: Amivantamab, JNJ-61186372 supplier, EGFR/HER2, inhibitors, activators

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