All AbMole products are for research use only, cannot be used for human consumption.
Amitriptyline (MK-230, N-750, Ro41575) is an inhibitor of the serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki values of 3.45 nM and 13.3 nM, respectively, and also inhibits the histamine receptor H1, the histamine receptor H4, 5-HT2, and the Sigma 1 receptor with Ki values of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. It can also inhibit histamine receptor H1, histamine receptor H4, 5-HT2 and Sigma 1 receptor with Ki values of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively, and can be used in studies of depression and neuropathic pain.
| Molecular Weight | 277.4 |
| Formula | C20H23N |
| CAS Number | 50-48-6 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Elliot W McClure, et al. ACS Chem Neurosci. Classics in Chemical Neuroscience: Amitriptyline
[3] No authors listed. Nurs Times. Amitriptyline and nortriptyline
| Related Serotonin Transporter Products |
|---|
| Adoxosidic acid
Adoxosidic acid is a SERT enhancer which can be extracted from N. jatamansi. |
| Centanafadine hydrochloride
Centanafadine hydrochloride is a potential first-in-class norepinephrine (NE), dopamine (DA), and 5-hydroxytryptamine (5-HT) reuptake inhibitor (NDSRI) with IC50 values of 6 nM, 38 nM, and 83 nM, respectively. It can be used in studies related to attention-deficit/hyperactivity disorder (ADHD). |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
