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Amitriptyline inhibits serotonin receptor, norepinephrine receptor, 5-HT4, 5-HT2 and sigma 1 receptor with IC50 of 3.45 nM, 13.3 nM, 7.31 nM, 235 nM and 287 nM, respectively.
| Molecular Weight | 313.86 |
| Formula | C20H23N.HCl |
| CAS Number | 549-18-8 |
| Solubility (25°C) | DMSO 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related 5-HT Receptor Products |
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| Buspirone
Buspirone is an orally active 5-HT1A receptor agonist, and a dopamine D2 autoreceptorsant antagonist. |
| Clomipramine Hydrochloride
Clomipramine HCl is a hydrochloride salt of clomipramine which is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively. |
| Quetiapine Sulfone
Quetiapine Sulfone is a 5-HT receptor agonist with a pEC50 value of 4.77 for human 5-HT1A. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 value of 6.33 for human D2. |
| Quetiapine sulfoxide
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| Iloperidone
Iloperidone, a serotonin (5-HT2) receptor inhibitor, is used to study schizophrenia. |
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