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Aminoxyacetic acid

Cat. No. M10390

All AbMole products are for research use only, cannot be used for human consumption.

Aminoxyacetic acid Structure
Synonym:

Carboxymethoxylamine; Aminooxyacetate

Size Price Availability Quantity
1mg USD 35 In stock
5mg USD 70 In stock
10mg USD 110 In stock
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Quality Control & Documentation
Biological Activity

Aminooxy-acetic acid (AOA) is a GABA transaminase (GABA-T) inhibitor (Ki = 9.16 μM) that induces GABA accumulation in the brain. It also inhibits cystathionine β synthase (CBS) and cystathionine γ lyase (CSE) with IC50 values of 8.5 and 1.1 μM, respectively. Aminooxyacetic acid (Carboxymethoxylamine) is a malate-aspartate shuttle (MAS) inhibitor.

Chemical Information
Molecular Weight 91.07
Formula C2H5NO3
CAS Number 645-88-5
Solubility (25°C) DMSO 50 mg/mL
Water
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Antonia Asimakopoulou, et al. Br J Pharmacol. Selectivity of commonly used pharmacological inhibitors for cystathionine β synthase (CBS) and cystathionine γ lyase (CSE)

[2] D P WALLACH. Biochem Pharmacol. Studies on the GABA pathway. I. The inhibition of gamma-aminobutyric acid-alpha-ketoglutaric acid transaminase in vitro and in vivo by U-7524 (amino-oxyacetic acid)

[3] W Loscher. Naunyn Schmiedebergs Arch Pharmacol. A comparative study of the pharmacology of inhibitors of GABA-metabolism

[4] W Loscher, et al. J Neurochem. Use of inhibitors of gamma-aminobutyric acid (GABA) transaminase for the estimation of GABA turnover in various brain regions of rats: a reevaluation of aminooxyacetic acid

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Keywords: Aminoxyacetic acid, Carboxymethoxylamine; Aminooxyacetate supplier, GABA Receptor, inhibitors, activators

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