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Amiloride hydrochloride

Cat. No. M3386

All AbMole products are for research use only, cannot be used for human consumption.

Amiloride hydrochloride Structure
Synonym:

MK-870 hydrochloride

Size Price Availability Quantity
100mg USD 60 In stock
500mg USD 110 In stock
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Quality Control & Documentation
Biological Activity

Amiloride hydrochloride (Midamor), a pyrazine compound inhibit sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with diuretics to spare potassium loss.

Product Citations
Chemical Information
Molecular Weight 266.09
Formula C6H8ClN7O.HCl
CAS Number 2016-88-8
Solubility (25°C) DMSO 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Qianhui Sun, et al. Amiloride: A review

[2] Venkata Yellepeddi, et al. Stability of extemporaneously compounded amiloride nasal spray

[3] Fadel Wedian, et al. Simultaneous spectrofluorometric analysis of tablets containing hydrochlorothiazide combined with timolol maleate or amiloride hydrochloride

[4] Arnault Massink, et al. Allosteric modulation of G protein-coupled receptors by amiloride and its derivatives. Perspectives for drug discovery?

[5] Seema Thakral, et al. Adduction of amiloride hydrochloride in urea through a modified technique for the dissolution enhancement

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Keywords: Amiloride hydrochloride, MK-870 hydrochloride supplier, Sodium Channel, inhibitors, activators

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