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AMG8379 is a potent, orally active and selective sulfonamide antagonist of the voltage-gated sodium channel NaV1.7, with IC50s of 8.5 and 18.6 nM for hNaV1.7 and mNaV1.7, respectively. AMG8379 potently and reversibly blocks endogenous Tetrodotoxin (TTX)-sensitive sodium channels in dorsal root ganglia (DRG) neurons with an IC50 of 3.1 nM.
| Molecular Weight | 543.93 |
| Formula | C25H16ClF2N3O5S |
| CAS Number | 1642112-31-9 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
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