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AMG-8718 

Cat. No. M27963

All AbMole products are for research use only, cannot be used for human consumption.

AMG-8718  Structure

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Quality Control & Documentation
Biological Activity

AMG-8718 is a potent, selective and orally active BACE1 inhibitor with IC50 values of 0.0007, 0.005 µM for BACE1 and BACE2, respectively. AMG-8718 significantly decreases Aβ40 levels in the CSF and brain.

Chemical Information
Molecular Weight 442.44
Formula C25H19FN4O3
CAS Number 1215868-94-2
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Thomas A Dineen, et al. J Med Chem. Inhibitors of β-site amyloid precursor protein cleaving enzyme (BACE1): identification of (S)-7-(2-fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine (AMG-8718)

[2] Mark R Fielden, et al. Toxicol Pathol. Retinal Toxicity Induced by a Novel β-secretase Inhibitor in the Sprague-Dawley Rat

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Abmole Inhibitor Catalog




Keywords: AMG-8718  supplier, Gamma-secretase/Beta-secretase, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
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