All AbMole products are for research use only, cannot be used for human consumption.
AMG 837 is a potent, orally bioavailable GPR40 agonist with EC50 of 14 nM.
 |
Source | Physiol Rep (2015). Figure 3. AMG-837 |
| Method | Hormone measurement | |
| Cell Lines | rat small intestine | |
| Concentrations | 10 μmol/L | |
| Incubation Time | - | |
| Results | Intergroup comparisons between LA, TAK-875, AMG 837, and DMSO stimulations showed that only the GLP-1 response induced by vascular AMG 837 was significantly different from the vehicle control |
| Molecular Weight | 438.44 |
| Formula | C26H21F3O3 |
| CAS Number | 865231-46-5 |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Jonathan B Houze, et al. AMG 837: a potent, orally bioavailable GPR40 agonist
| Related GPR/FFAR Products |
|---|
| GW9508
GW9508 is a potent and selective G protein-coupled receptors FFA1 (GPR40) and GPR120 agonist with pEC50s of 7.32 and 5.46, respectively. GW9508 has anti-inflammatory and anti-atherosclerotic activities. GW9508 is a glucose-sensitive insulin secretagogue and an ATP-sensitive potassium (KATP) channels opener. |
| Fasiglifam (TAK-875) Hemihydrate
Fasiglifam (TAK-875) Hemihydrate is a novel, orally available, selective GPR40 agonist. |
| OC000459
OC000459 is a potent, selective, and orally active D prostanoid receptor 2 antagonist. |
| AZD1981
AZD1981 is a potent, selective CRTh2 (DP2) receptor antagonist with IC50 of 4 nM, showing >1000-fold selectivity over more than 340 other enzymes and receptors, including DP1. |
| GSK1292263
GSK1292263 is a novel GPR119 agonist, showing potential for the treatment of type 2 diabetes. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
