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AMG-221 

Cat. No. M27787

All AbMole products are for research use only, cannot be used for human consumption.

AMG-221  Structure

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Quality Control & Documentation
Biological Activity

AMG-221 is an inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) with a Ki of 12.8 nM in vitro biochemical scintillation proximity assay (SPA) and an IC50 of 10.1 nM in cell-based assays. AMG-221 can be used for the research of type 2 diabetes.

Chemical Information
Molecular Weight 266.4
Formula C14H22N2OS
CAS Number 1095565-81-3
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Qiuxia Gao, et al. Xenobiotica. Intestinal and hepatic first-pass extraction of the 11β-HSD1 inhibitor AMG 221 in rats with chronic vascular catheters

[2] John P Gibbs, et al. J Clin Pharmacol. Population pharmacokinetic/pharmacodynamic model of subcutaneous adipose 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) activity after oral administration of AMG 221, a selective 11β-HSD1 inhibitor

[3] Seb Caille, et al. J Org Chem. Two asymmetric syntheses of AMG 221, an inhibitor of 11beta-hydroxysteroid dehydrogenase type 1

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  Catalog
Abmole Inhibitor Catalog




Keywords: AMG-221  supplier, Hydroxysteroid dehydrogenase, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
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