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Amcinonide

Cat. No. M20791

All AbMole products are for research use only, cannot be used for human consumption.

Amcinonide Structure
Synonym:

Cyclocort, CL-34699

Size Price Availability Quantity
50mg USD 85 In stock
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Quality Control & Documentation
Biological Activity

Amcinonide (Cyclocort, CL-34699) is an inhibitor of nitric oxide (NO) release from activated microglia with IC50 of 3.38 nM.

Chemical Information
Molecular Weight 502.57
Formula C28H35FO7
CAS Number 51022-69-6
Solubility (25°C) DMSO 84 mg/mL
Water 84 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] No authors listed. Amcinonide

[2] A C Huntley, et al. Cutis. Amcinonide vs. betamethasone dipropionate ointments in the treatment of psoriasis

[3] R Hayakawa, et al. Contact Dermatitis. Allergic contact dermatitis from amcinonide

[4] Y Kubo, et al. Contact Dermatitis. Contact allergy to amcinonide

[5] D Lubach, et al. Dermatologica. Investigations on the development and regression of corticosteroid-induced thinning of the skin in various parts of the human body during and after topical application of amcinonide

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Imperatorin

Imperatorin is a potent NO synthesis inhibitor with an IC50 of 9.2 μmol and a BChE inhibitor with an IC50 of 31.4 μmol. Imperatorin is a weak agonist of TRPV1 with an EC50 of 12.6±3.2 μM.

Crocin-II

Crocin II, isolated from the fruit of Gardenia jasminoides, has antioxidant, anticancer and antidepressant activities. Crocin II inhibited NO production with IC50 value of 31.1 μM. Crocin II inhibited the expression of iNOS and COX-2 protein and M-RNA.

Madecassic-acid

Madecassic acid was isolated from Centella asiatica (umbelliferae). Madecassic acid showed inhibition of iNOS, COX-2, TNF-α, IL-1beta and IL-6, and had anti-inflammatory effect by down-regulation of NF-κB activation in RAW 264.7 macrophages.

Irisflorentin

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Keywords: Amcinonide, Cyclocort, CL-34699 supplier, NO Synthase, inhibitors, activators

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