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AM-2201 is a potent synthetic cannabinoid (CB) with Ki values of 1.0 and 2.6 nM for the CB1 and CB2 receptors, respectively. AM-2201 acts as a potent but nonselective full agonist for the cannabinoid receptor. The physiological actions and metabolism of AM2201 have not been characterized.
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Source | Drug Alcohol Depend (2017). Figure 2. AM2201 |
| Method | s.c. | |
| Cell Lines | Rats | |
| Concentrations | 0.1 – 0.3 mg/kg | |
| Incubation Time | 3 h | |
| Results | THC and XLR-11 were the least potent of the cannabinoids, while CP55,940 was the most potent. JWH-018 and AM2201 had comparable potency at increasing BP and were intermediate between CP55,940 and THC. |
| Molecular Weight | 359.44 |
| Formula | C24H22FNO |
| CAS Number | 335161-24-5 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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| CP 945598 hydrochloride
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| AM251
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| BML-190
BML-190 is a selective cannabinoid CB2 receptor inverse agonist with Ki of 435 nM, with 50-fold selectivity over CB1 receptor. |
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