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Alvimopan is a gastroprokinetic peripheral mu-opioid receptor antagonist. As a drug, Alvimopan is given to patients undergoing bowel surgery to protect the bowel from the effects of opioid medications that are used to treat pain, blocking the undesirable GI side-effects of the opioid agonists without affecting analgesia or causing withdrawal. Alvimopan does not cross the blood-brain barrier, competitively binding to gastrointestinal tract mu-opioid receptors.
| Molecular Weight | 424.53 |
| Formula | C25H32N2O4 |
| CAS Number | 156053-89-3 |
| Solubility (25°C) | DMSO: 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Shahnaz Sultan, et al. Alvimopan for recovery of bowel function after radical cystectomy
[2] Heather R Bream-Rouwenhorst, et al. Alvimopan for postoperative ileus
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