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Alvimopan dihydrate (ADL 8-2698 dihydrate) is a potent, selective, orally active and reversible μ-opioid receptor antagonist, with an IC50 of 1.7 nM. Alvimopan dihydrate has selectivity for μ-opioid receptor (Ki=0.47 nM) over κ- and δ-opioid receptors (Kis=100, 12 nM, respectively).
| Molecular Weight | 460.56 |
| Formula | C25H36N2O6 |
| CAS Number | 170098-38-1 |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Opioid Receptor Products |
|---|
| ADL5859 Hydrochloride
ADL5859 is a potent, selective and orally bioavailable δ-opioid receptor agonist (Ki = 0.84 nM, EC50 = 20 nM). |
| JTC-801
JTC-801 is a novel opioid receptor-like1 (ORL1) receptor antagonist with IC50 of 94 nM. |
| Meptazinol hydrochloride
Meptazinol is a unique centrally active opioid analgesic, which inhibits [3H]dihydromorphine binding with IC50 of 58 nM. |
| Nalmefene hydrochloride
Nalmefene is an opioid receptor antagonist, it is used primarily in the management of alcohol dependence. |
| Naloxone hydrochloride
Naloxone hydrochloride is an opioid inverse agonist compound used to counter the effects of opiate overdose. |
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