All AbMole products are for research use only, cannot be used for human consumption.
Aloperine is an isolated alkaloid in sophora plants such as Sophora alopecuroides L, which exhibits anti-inflammatory, antibacterial, antiviral, and anti-tumor properties. Aloperine treatment potently inhibits the swelling of the rat's hind paw induced by injecting carrageenin, macostatin, PGE2, histamine, or 5-HT, suppresses the rat's scald oedema induced by scalding its hind paw, and blocks the increased permeability of capillaries caused by histamine and the leukocytic migratory response. Aloperine treatment greatly improves the 2, 4-dinitrofluorobenzene (DNFB)-induced allergic contact dermatitis in BALB/c mice, which might be related to the reduction of TNF-alpha, IL-1beta and IL-6 production induced by DNFB. Aloperine exerts the most potent in vitro cytotoxic activity against the human cancer cell lines, compared with other Sophora flavescens Ait. (SF) derived quinolizidine alkaloids including sophoridine, sophocarpine, matrine, oxymatrine and cytisine. Aloperine treatment also significantly inhibits dermatitis index and ear thickness in DNFB-treated NC/Nga mice in a dose-dependent manner. Eosinophils, mast cells infiltration into the ears and plasma level of immunoglobulin (Ig) E are also suppressed by Aloperine treatment. Topical application of Aloperine increases the immunosuppressive cytokine IL-10 level, while it reduces other cytokines production in a dose-dependent manner. Clinically, Aloperine has been widely used in China for decades to treat patients with allergic contact dermatitis, eczema and other skin inflammation.
| Molecular Weight | 232.36 |
| Formula | C15H24N2 |
| CAS Number | 56293-29-9 |
| Form | Solid |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Apoptosis Products |
|---|
| 23-Hydroxybetulinic acid
23-Hydroxybetulinic acid is a novel anticancer substance. |
| TH-302 (Evofosfamide)
TH-302 is a highly potent and selective hypoxia-activated procompound targeting hypoxic regions of solid tumors with IC50 of 19 nM. |
| Se-Methylselenocysteine
Se-methylselenocysteine, a precursor of methyl selenium, has strong cancer chemoprophylaxis and antioxidant activity. Se-Methylselenocysteine has oral biological activity, can induce apoptosis. |
| Ezatiostat
Ezatiostat (TER199, TLK199) is a glutathione analog inhibitor of glutathione S-transferase (GST) P1-1. Ezatiostat leads to JNK activation by inhibiting GSTP1. Ezatiostat stimulates both lymphocyte production and bone marrow progenitor proliferation. |
| Ibandronate sodium
Ibandronate sodium is a potent nitrogen-containing bisphosphonate that can be used in studies related to osteoporosis. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
