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Allopurinol (Zyloprim) is a xanthine oxidase inhibitor with an IC50 of 7.82?.12 uM. Xanthine oxidase is responsible for the successive oxidation of hypoxanthine and xanthine resulting in the production of uric acid, the product of human purine metabolism. The inhibition of XO activity by 6-aminopurine (IC50=10.89?.13 uM) and its analogues was compared with that by allopurinol (IC50=7.82?.12 uM). Among these analogues, 2-chloro-6 (methylamino)purine (IC50=10.19?.10 uM) and 4-aminopyrazolo[3,4-d] pyrimidine (IC50=30.26?.23 uM) were found to be potent inhibitors of XO.
| Molecular Weight | 136.11 |
| Formula | C5H4N4O |
| CAS Number | 315-30-0 |
| Form | Solid |
| Solubility (25°C) | DMSO 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Richard O Day, et al. Allopurinol: insights from studies of dose-response relationships
[2] Lisa K Stamp, et al. Allopurinol and kidney function: An update
[3] Anita Kelkar, et al. Allopurinol as a cardiovascular drug
[4] Arie Markel. Allopurinol-induced DRESS syndrome
[5] M McNaughton Collins, et al. Allopurinol for chronic prostatitis
| Related Xanthine Oxidase Products |
|---|
| Febuxostat (TEI-6720)
Febuxostat (TEI-6720) is a non-purine selective xanthine oxidase inhibitor with IC50 of 114 -210 nM. |
| Allopurinol Sodium
Allopurinol Sodium is a xanthine oxidase inhibitor and a structural isomer of hypoxanthine with an IC50 of 7.82 ± 0.12 μM, which inhibits the conversion of xanthine to uric acid and increases the reuse of hypoxanthine and xanthine in nucleic acid synthesis, thereby reducing serum and urinary uric acid levels, and can be used in gout-related studies. |
| Topiroxostat
Topiroxostat (FYX-051) is a novel and potent xanthine oxidoreductase (XOR) inhibitor with IC50 value of 5.3 nM. |
| Broussoflavonol F
Broussoflavonol F has xanthine oxidase inhibitory activity. |
| Vanillic acid
Vanillic acid inhibits NF-κB activation. Vanillic acid has anti-inflammatory, antibacterial, and chemopreventive effects. |
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