All AbMole products are for research use only, cannot be used for human consumption.
Alendronate is a farnesyl diphosphate synthase inhibitor with IC50 of 460 nM. It is a nitrogen-containing bisphosphate that acts as a robust inhibitor of bone resorption and induces apoptosis in osteoclasts. It causes disruption of the ruffled border and actin cytoskeleton of osteoclasts and induces in vitro apoptosis of osteoclasts and macrophages by inhibiting farnesyl diphosphate synthase (IC50 = 460 nM). It efficiently chelates metal ions and functions as a broad-spectrum MMP inhibitor (IC50 ~ 40 - 70 uM). And it also displays antimetastatic, anti-invasive and cell-adhesion-promoting properties (IC50 ~ 1 pM, in vitro invasion of prostate cancer cells).
Patent. EP4489722A1 2025 Jan 15; .
Patent. EP4489722A1
Alendronate sodium hydrate purchased from AbMole
Patent. CN118785884A 2024 Oct 15.
Patent. CN118785884A
Alendronate sodium hydrate purchased from AbMole
Patent. KR20240161812A 2024 Nov 12.
Patent. KR20240161812A
Alendronate sodium hydrate purchased from AbMole
Patent. WO2023170311A1 2023-09-14.
Patent. WO2023170311A1
Alendronate sodium hydrate purchased from AbMole
Patent. WO2023170311A1 2023 Sep 14; .
Patent. WO2023170311A1
Alendronate sodium hydrate purchased from AbMole
| Molecular Weight | 326.13 |
| Formula | C4H13NO7P2.3H2O.Na |
| CAS Number | 121268-17-5 |
| Solubility (25°C) | Water 10 mg/mL warmed |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Gennady Ananchenko, et al. Alendronate sodium
[2] W P Olszynski, et al. Alendronate for the treatment of osteoporosis in men
[3] Neil A Reynolds, et al. Alendronate/colecalciferol
| Related Products |
|---|
| Lactate calcium
Lactate calcium is an excellent calcium fortifier that works better than inorganic calcium. Lactate calcium is used as an antacid. |
| Coniferyl ferulate
Coniferyl ferulate is a potent glutathione S-transferase (GST) inhibitor that reverses multidrug resistance and down-regulates p-glycoprotein. Coniferyl ferulate strongly inhibited human placental glutathione S-transferase with IC50 of 0.3 μM. |
| NXY-059
NXY-059 is a free radical-trapping neuroprotectant that has been reported to reduce infarct size and preserve brain function in experimental models of acute ischemic stroke. |
| Tie2 kinase inhibitor
Tie2 kinase inhibitor is a potent, reversible, and ATP-binding site-targeting Tie2 inhibitor with an IC50 of 250 nM. |
| Calcium levofolinate
Calcium levofolinate is a calcium salt of folinic acid that is an adjuvant used in cancer chemotherapy. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
