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AL-438 

Cat. No. M29590

All AbMole products are for research use only, cannot be used for human consumption.

AL-438  Structure

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Quality Control & Documentation
Biological Activity

AL-438 is a potent, selective and orally active glucocorticoid receptor modulator with Kis of 2.5, 1786, 53, 1440, >1000 nM for glucocorticoid receptor, progesterone receptor, mineralocorticoid receptor, androgen receptor, estrogen receptor, respectively. AL-438 shows antiinflammatory activity.

Chemical Information
Molecular Weight 347.45
Formula C23H25NO2
CAS Number 239066-73-0
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Mei Yang, et al. Pharmacol Res. Dimerization of glucocorticoid receptors and its role in inflammation and immune responses

[2] Arvind Chopra. [11C]10-Methoxy-5-(2-propenyl)-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinoline

[3] H C Owen, et al. Mol Cell Endocrinol. The growth plate sparing effects of the selective glucocorticoid receptor modulator, AL-438

[4] Jonathan Rosen, et al. Endocr Rev. The search for safer glucocorticoid receptor ligands

[5] Sheila Doggrell. Expert Opin Investig Drugs. Is AL-438 likely to have fewer side effects than the glucocorticoids?

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Keywords: AL-438  supplier, GCR, inhibitors, activators

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