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AKT Kinase Inhibitor is an Akt kinase inhibitor with anti-tumor activity.
| Molecular Weight | 357.37 |
| CAS Number | 842148-40-7 |
| Solubility (25°C) | DMSO 16.67 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Jessika Bertacchini, et al. Targeting PI3K/AKT/mTOR network for treatment of leukemia
[4] Jenny Bain, et al. The selectivity of protein kinase inhibitors: a further update
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| Perifosine
Perifosine is an orally active Akt inhibitor, the antiproliferative properties of Perifosine with an IC50 of 0.6–8.9 µM. |
| MK-2206 2HCl
MK-2206 is a novel allosteric inhibitor of Akt with IC50 values of 8 nM, 12 nM and 65 nM for Akt1, Akt2 and Akt3, respectively. |
| Ipatasertib
Ipatasertib (GDC-0068, RG7440) is a potent and selective, ATP-competitive Akt inhibitor with IC50 values of 5 to 18 nM. |
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